Metabolic Reprogramming in Arginine Deiminase-Resistant Cells
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Authors’ Affiliations: Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida; Department of Neurology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland *These authors contributed equally Corresponding Author: Macus Tien Kuo, Ph.D. Department of Translational Molecular Pathology, Unit 951, Room 2SCR4.3025, The University of Texas MD Anderson Cancer Center, 7435 Fannin Blvd, Houston, TX 77054; Tel: 713-834-6038, Fax: 713-834-6085; E-mail: [email protected] Running Title: Metabolic Reprogramming in Arginine Deiminase-Resistant Cell
منابع مشابه
Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction.
Many malignant human tumors, including melanomas, are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase-1 (ASS1), the rate-limiting enzyme for arginine biosynthesis. Pegylated arginine deiminase (ADI-PEG20), which degrades extracellular arginine, resulting in arginine deprivation, has shown favorable results in clinical trials for treating arginine-auxotrophic t...
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Many malignant human tumors, including melanomas, are auxotrophic for arginine due to reduced expression of argininosuccinate synthetase-1 (ASS1), the rate-limiting enzyme for arginine biosynthesis. Pegylated arginine deiminase (ADI-PEG20), which degrades extracellular arginine, resulting in arginine deprivation, has shown favorable results in clinical trials for treating arginine-auxotrophic t...
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متن کاملPotent Growth Inhibition of Human Tumor Cells in Culture by Arginine Deiminase Purified from a Culture Medium of a Mycoplasma-infected Cell Line1
Two kinds of growth-inhibitory substances were found in culture of a Rous sarcoma virus-transformed rat liver cell line, RSV-BRL. The two substances were purified from the serum-free culture medium and iden tified as transforming growth factor ß, and Mycoplasma-áerÃ-\edarginine deiminase (EC 3.5.3.6), respectively. The arginine deiminase was an acidlabile but dithiothreitol-resistant protein ...
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تاریخ انتشار 2013